Initial studies have shown that a marketed TNF-α antagonist, Etanercept (Pfizer and others) can reverse the effects of age-related constipation in this mouse model. N2 - Researchers at the University of Brighton have studied the underpinning biology and physiology of the ageing bowel which has implicated age-related changes in TNF-α expression as a cause of changes in faecal output in healthy older mice. T1 - BBSRC Pathfinder - Technology Market Assessment and Patent Landscape Analysis for use of TNF-α Antagonists in the Management of Constipation in the Elderly Since many people self-treat, only a small number of patients seek medical help.", About 20% of the general populationexperiences problems with constipation during their life time, with elderly people and women being more commonly affected. Primary forms also occur, but are less common. The aetiology of constipation is usually multifactorial, and may include diet, structural issues, other disease conditions and medications. Chronic constipation can significantly affect an individuals quality of life and may be associated with significant health care costs. Constipation is considered chronic if it is present for a total of at least 12 weeks (nonconsecutively) in any one year period.
It is not a well-defined disease entity, but a general collection of symptoms. Constipation is experienced by both humans and animals, so this opportunity is relevant to both human and animal health. Although TNF-α antagonists are safe for chronic usage in elderly patients, the drug can suppress the immune system and these factors need to be taken into account when prescribing these drugs for the longterm treatment of the elderly. This type of drug is currently prescribed for rheumatoid arthritis and ulcerative colitis, and is a biological molecule which is infused via injection and is expensive to manufacture. Since many people self-treat, only a small number of patients seek medical help.Ībstract = "Researchers at the University of Brighton have studied the underpinning biology and physiology of the ageing bowel which has implicated age-related changes in TNF-α expression as a cause of changes in faecal output in healthy older mice. About 20% of the general populationĮxperiences problems with constipation during their life time, with elderly people and women being more commonly affected. Chronic constipation can significantly affect an individual’s quality of life and may be associated with significant health care costs.
Researchers at the University of Brighton have studied the underpinning biology and physiology of the ageing bowel which has implicated age-related changes in TNF-α expression as a cause of changes in faecal output in healthy older mice.
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